Development of n-HA/CS-GM biomimetic nanocomposite for biomedical applications

Nowadays, effective treatment and management of malignant osteomyelitis remain an alarming clinical challenge causing the creation antimicrobial biomaterials for orthopedic surgeons. The has revived attention in creating orthopedics. collaboration nanotechnology engineered will probably provide perception developing novel hybrid composites. Because improved control interaction between nanoparticles polymers, nanohydroxyapatite (n-HA) incorporated nanocomposite would versatility designing specific properties. As a result, study describes ethanolic extraction Guar gum from native Cassia fistula seeds, as well development (n-HA), Chitosan (CS), (GM) via Co-precipitation method. nanocomposites were characterized based on their physicochemical morphological properties, such XRD, FT-IR, SEM. tested antibacterial activity against Staphylococcus aureus(S.aureus) ATCC25923 anticancer MG 63 (osteosarcoma) cancer cell line MTT assay. result confirms that n-HA/CS-GM exhibit excellent properties aureus average inhibition zones different content samples S. 15.75 mm n-HA/CS 19.75 microspheres, respectively. cytotoxicity showed OD cells treated with 7.8 to 1000 µg/mL concentration composite varied 0.479 0.297 parallel 88.70% 55% viability, 0.447 0.273 corresponding 82.77% 50.55% viability 7.8µg/mL up 1000µg/mL.